Cell-loaded microcarriers form an unique cell delivery system to damaged or degenerated tissue for repair and restoration of function, while enhancing cell retention. Cell harvesting is considered as one of the main obstacles of using microcarriers in 3D cell culturing processes. Fujifilm's new injectable microcarrier eliminates the need for cell harvesting after cell expansion.
Leveraging on Fujifilm’s human collagen I based Cellnest biomaterial, a revolutionary new injectable microsphere has been developed for cell delivery to patients. After cell expansion, the microcarrier plus the cells can be administered together without the additional need of cell harvesting. The macroporous microspheres have a size range of 100-400 µm, which make them suitable for injection. Their macroporous structure provide an artificial microenvironment allowing cell-cell and cell-matrix interaction in all three dimension, together with a high nutrient and gas exchange rate.
Fujifilm's macroporous microspheres are suitable
- As minimally invasive cell delivery vehicle to patients, without the need for cell harvesting
- As microcarriers to grow cells onto
- For anchorage dependent cell production
- In dynamic expansion systems like spinner flasks and bioreactors