Scaffolds or matrices based on extracellular matrix (ECM)-inspired biomaterials play a central role in the repair of tissue damage. Cell matrices can optimise the physiologically relevant 3D microenvironment of the cells and prevent graft cell death
To make a tissue, cells need to be build up in a complex 3D structure similar to their natural structure in the ECM. The behaviour of cells is affected by their physical environment. Hydrogels are often used as matrix for tissue engineering and organ-on-a-chip applications because they can closely mimic the physically relevant microenvironment of the extracellular matrix.